[ TU/e -> CASA -> Mark Peletier -> Partial Localization ]


Collaborators:
Yves van Gennip
Felix Otto Matthias Röger
Marco Veneroni

Partial Localization and the stability of lipid bilayers

To explain partial localization we first need to explain localization.

Localization of deformation is a common phenemenon in large or long elastic structures, in which deformation in a buckled structure does not extend throughout the structure, but remains confined to a small part of it. This is explained in more detail in a different page. Similarly, solutions of reaction-diffusion equations may also show localization into what are called spike-layer solutions: such solutions only take non-trivial values in the neighbourhood of a small number of points:


non-localized

localized into spike-layer solutions

Partially localized ‘structures’ are solutions of some kind of equation (to be detailed later) that are thin, localized, in some directions, and large, non-localized, in others. Doelman & Van der Ploeg showed that a Gierer-Meinhardt system has solutions in two dimensions that are stable and only depend on one variable; they look like


localized in one direction, not in the other: partially localized

Variational analysis

This phenomenon takes an interesting turn in the context of variationally-defined systems, systems that are characterized by an energy functional. This is an important class; the membranes that separate the different parts of our body's cells are examples of such systems, and their structural and mechanical properties have been studied already in the 70's, starting with the work of Helfrich.

a lipid bilayer
A lipid bilayer consists of unlinked lipid molecules

Lipid bilayers show a surprising feature: although at a microscopic scale they consist of molecules without covalent bonding, they show at a macroscopic scale a behaviour similar to that of elastic membranes. While Helfrich postulated this behaviour up-front, in the form of a surface density of elastic energy, it is one of our main interests to understand how this connection between low-level uncoupling and high-level coupling is achieved.

It would be nice to relate an energy-based description of lipid bilayers to the simple surface energy density of Helfrich. Since no useful microscopic description of lipid bilayers is available - because for systems of this type a faithful continuum description is not possible - we make do with a crude approximation, which shows the main features without being too complicated for analysis.

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Last modified on January 6, 2015 by Mark Peletier