Recent studies have demonstrated the feasibility of High-Intensity Focused Ultrasound (HIFU) therapy for bone metastases by ablating the source of pain. Adoption of this new technique relies on the ability to measure and simulate the temperature and ablated tissue with high accuracy. For therapy of soft tissue this is measured directly using Magnetic Resonance Imaging (MRI), however this is not possible inside bone. Because of this the therapy is simulated using software to determine the local temperature and corresponding ablated region. The golden standard for solving this is the wave equation, however this is too computationally expensive for clinical applications. Because of this the wave equation is approximated using a ray-tracing simulation which was developed prior to this project. This report describes the implementation and configuration of the ray-tracing module to compute the heat production, which is then used in a bio-heat simulation that describes the temperature over time. These temporal results are used to compute the ablated tissue on and around the bone during a therapy. The main focus of this project is to unify all of the previously separate steps in a single pipeline and to improve the performance. To proof the validity of the simulation experiments on pig and rabbit bone are compared to the original prototype and empirical results. Important for such a simulation is being able to analyse the intermediate results of each of the steps in the pipeline in great detail. Because of this extensive visualisation and analysis tools have been implemented which are also integrated into the same pipeline.